Metinel Node—The First Lymph Node Draining a Metastasis—Contains Tumor-Reactive Lymphocytes
نویسندگان
چکیده
منابع مشابه
CD8+ T Lymphocyte Subsets in Bladder Tumor Draining Lymph Nodes
Background: Cytotoxic CD8+ T cells, as essential parts of the adaptive immune system, play pivotal roles in anti-tumor immune responses. It is well documented that cytokine expression profiles and activation status of these cells during anti-tumor immune responses affect the outcome of host-tumor interaction. Objective: To investigate the percentages of CD8+ lymphocytes and their subsets in...
متن کاملImmortalization of human lymphocytes from a tumor-involved lymph node.
Lymphocytes isolated from a regional draining lymph node of a patient with a carcinoma of the vulva were fused with human UC 729-6 cells. The generated human-human hybridomas were tetraploid with the 21p+ chromosomal marker of UC 729-6, expressed HLA derived from the patient's cells, and have been stable in culture for 2 yr. Supernatants from six immunoglobulin G (IgG)-secreting hybridomas were...
متن کاملLIGHT regulates inflamed draining lymph node hypertrophy.
Lymph node (LN) hypertrophy, the increased cellularity of LNs, is the major indication of the initiation and expansion of the immune response against infection, vaccination, cancer, or autoimmunity. The mechanisms underlying LN hypertrophy remain poorly defined. In this article, we demonstrate that LIGHT (homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprot...
متن کاملActivation by anti-CD3 of tumor-draining lymph node cells for specific adoptive immunotherapy.
Lymph nodes draining progressive tumors contain tumor-sensitized but not functional preeffector T lymphocytes. These cells can acquire antitumor reactivity after stimulation with tumor cells and interleukin-2 (IL-2). We demonstrated here that, in the absence of tumor cells, preeffector cells could be stimulated and expanded by sequential culture with anti-CD3 monoclonal antibody and IL-2. The a...
متن کاملRegulation of Dendritic Cell Migration to the Draining Lymph Node
Antigen-pulsed dendritic cells (DCs) are used as natural adjuvants for vaccination, but the factors that influence the efficacy of this treatment are poorly understood. We investigated the parameters that affect the migration of subcutaneously injected mouse-mature DCs to the draining lymph node. We found that the efficiency of DC migration varied with the number of injected DCs and that CCR7+/...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of Surgical Oncology
سال: 2008
ISSN: 1068-9265,1534-4681
DOI: 10.1245/s10434-007-9788-7